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Parainfluenza Virus Vaccine

5 Jun

The  human parainfluenza virus (HPIV)  contains two  viral glycoproteins in  the  viral envelope. Human parainfluenza viruses are  closely  related to the  measles, mumps, and  respi- ratory syncytial viruses. Human parainfluenza virus type  3 is the  second leading cause of infant and  childhood respira- tory  disease (after RSV). Currently, no vaccine or antiviral is available. The [...]

Respiratory Syncytial Virus Vaccine

5 Jun

Respiratory syncytial virus (RSV) is the  most  common cause of severe lower  respiratory tract  infection in  infants and young  children which results in  nearly 100,000 hospitaliza- tions and  4500 dead in the  United States each  year (295).
Premature infants and  those with chronic lung  disease or congential heart disease are  most  susceptible, as are  bone-mar- row [...]

Human Papillomavirus Vaccine

5 Jun

Because certain subtypes of human papillomavirus (HPV) are associated with the  development of cervical cancer, the  search for  a  prophylactic or  therapeutic HPV  vaccine has  been  an important endeavor. Although more  than 30 types of HPV are known to be sexually transmittable, the  major types associ- ated with malignancy (HPV-16, -18, -31, -33, -45, -52, [...]

HERPES SIMPLEX VIRUS VACCINE

5 Jun

Herpes simplex (HSV-1 and-2) viruses are  discussed in Chap- ter 3. The  search for a vaccine for herpes simplex virus (HSV-1 and-2) spans eight decades. In the  1920s, untreated  vesicu- lar  fluid  from  herpes lesions was  injected into  patients in an attempt to  induce immunity (212).  This  method, to  say  the least, did  not  withstand [...]

Human Immunodeficiency Virus Vaccine

5 Jun

A review of HIV  infection and  transmission can  be found  in Chapter 2.  As  the  AIDS  epidemic persists  and   spreads unabated in much of the  world,  the  search for an  effective HIV vaccine is becoming critical. In  1997,  President Clinton chal- lenged scientists to  develop an  effective HIV  vaccine by the year 2007.  Since  clinical [...]