Translocation

4 Apr

Translocation

Translation
tion rate for eukaryotic cells is much slower (e.g., two amino acids per second in red blood cells in vitro). Compare replication rate, transcription rate. translocase a protein that forms a complex with GTP and the ribosome. Translocation of the charged tRNA from the A site to the P site is coupled with the hydrolysis of GTP to GDP and with the release of the translocase. See elongation factors, mitochon- drial pore-forming translocases, translation. translocation 1. the movement of mRNA through a ribosome during translation (q.v.) Each transloca-

tion exposes an mRNA codon in the A site for base pairing with a tRNA anticodon. 2. a chromosome aberration which results in a change in position of a chromosomal segment within the genome, but does not change the total number of genes present. Vari- ous types of translocations are illustrated on page 454. An intrachromosomal translocation is a three- break aberration that results in the transposition of a chromosomal segment to another region of the same chromosome. Such an aberration is often called a shift. Interchromosomal translocations involve inter- changes between nonhomologous chromosomes. A


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