TREATMENT OF FEMALE ORGASMIC DISORDER

19 May

TREATMENT  OF  FEMALE  ORGASMIC DISORDER

Female  orgasmic disorder has  been  treated  from  psychoanalytic, cognitive- behavioral, pharmacological,  and systems theory perspectives (69). Because substantial empirical outcome research is available only for cognitive-behavioral and, to a lesser degree, pharmacological approaches, only these two methods of treatment will be reviewed here.

Cognitive-Behavioral Approaches

Cognitive-behavioral therapy for female orgasmic disorder aims at promoting changes in attitudes and sexually relevant thoughts, decreasing anxiety, and increasing orgasmic ability and satisfaction. Traditionally, the behavioral exer- cises  used  to  induce  these  changes  include  directed  masturbation,  sensate focus, and systematic desensitization. Sex education, communication skills train- ing, and Kegel exercises are also often included in cognitive-behavioral treatment programs for anorgasmia.

Directed  Masturbation

Masturbation exercises are believed to benefit women with orgasm difficulties for a number of reasons. To the extent that focusing on nonsexual cues can impede sexual performance (70), masturbation exercises can help the woman to direct her attention to sexually pleasurable physical sensations. Because masturbation can be performed alone, any anxiety that may be associated with partner evaluation is necessarily eliminated. Relatedly, the amount and intensity of sexual stimu- lation is directly under the woman’s control and therefore the woman is not reliant upon her partner’s knowledge or her ability to communicate her needs to her partner. Research that shows a relation between masturbation and orgasmic ability provides empirical support for this treatment approach. Kinsey et al. (1) reported that the average woman reached orgasm 95% of the time she engaged in masturbation compared with 73% during intercourse. More recently, in a random probability sample of 682 women, Laumann et  al.  (60) reported a strong relation between frequency of masturbation and orgasmic ability during masturbation. Sixty-seven percent of women who masturbated one to six times a year reported orgasm during masturbation compared with 81% of women who masturbated once a week or more.

LoPiccolo and Lobitz (71) were the first to outline a program of directed masturbation (DM). Since then, several other researchers have provided vari- ations  (72,73).  The  first step  of  DM  involves  having  the  woman  visually examine her nude body with the help  of a mirror and diagrams of female genital anatomy. During the next stage she is instructed to explore her genitals tactually as well as visually with an emphasis on locating sensitive areas that produce feelings of pleasure. Once pleasure-producing areas are located, the woman is instructed to concentrate on manual stimulation of these areas and to increase the intensity and duration until “something happens” or until discomfort arises. The use of topical lubricants, vibrators, and erotic videotapes are often incorporated  into  the  exercises.  Once  the  woman  is  able  to  attain  orgasm alone, her partner is usually included in the sessions in order to desensitize her to displaying arousal and orgasm in his presence, and to educate the partner on how to provide her with effective stimulation.

DM has been used to effectively treat female orgasmic disorder in a variety of treatment modalities including group, individual, couples therapy, and bibliotherapy. A  number of  outcome  studies and  case  series  report  DM  is highly successful for treating primary anorgasmia. Heinrich (74) reported a 100% success rate for treating primary anorgasmia using therapist DM training at 2 month follow-up. The study was a controlled comparison of therapist- directed group masturbation training, self-directed masturbation training (bibliotherapy), and wait-list control. Forty-seven percent of the bibliotherapy subjects reported becoming orgasmic during masturbation compared with 21% of wait-list controls. In a randomized trial comparing written vs. videotaped mas- turbation assignments, the effects of self-directed masturbation training were further investigated (75). Sixty-five percent of women who used a text and

55% of women who used videotapes had experienced orgasm during masturba ion and 50% and 30%, respectively, were orgasmic during intercourse after 6 weeks. None of the control women had attained orgasm. Few controlled studies have examined the exclusive effects of DM for treating secondary anor- gasmia. Fichen et al. (76) compared minimal therapist contact bibliotherapy with a variety of techniques including DM and found no change in orgasmic ability. Hurlbert and Apt (77) recently compared the effectiveness of DM with coital alignment technique in 36 women with secondary anorgasmia. Coital alignment is a technique in which the woman assumes the supine position and the man pos- itions himself up forward on the woman. After only four 30-min sessions, 37% of women receiving instructions on coital alignment technique vs. 18% of those receiving DM reported substantial improvements (.50% increase) in orgasmic ability during intercourse. The benefits of this technique are due to the fact that clitoral contact, and possibly paraurethral, stimulation are maximized.

In summary, DM has been shown to be an empirically valid, efficacious treatment for women diagnosed with primary anorgasmia. For women with secondary anorgasmia, who are averse to touching their genitals, DM may be beneficial. If, however, the woman is able to attain orgasm alone through mastur- bation but not with her partner, issues relating to communication, anxiety reduction,  trust, and  ensuring the  woman is  receiving  adequate  stimulation either via direct manual stimulation or engaging in intercourse using positions designed  to  maximize  clitoral  stimulation  (i.e.,  coital  alignment  technique) may prove more beneficial.

Anxiety Reduction  Techniques

Anxiety could feasibly impair orgasmic function in women via several cognitive processes. Anxiety can serve as a distraction that disrupts the processing of erotic cues by causing the woman to focus instead on performance related concerns, embarrassment, and/or guilt. It can lead the woman to engage in self-monitoring during sexual activity, an experience Masters and Johnson (78) referred to as “spectatoring”. Physiologically, for many years it was assumed that the increased sympathetic activation that accompanies an anxiety state may impair sexual arousal necessary for orgasm via inhibition of parasympathetic nervous system activity. Meston and Gorzalka (79 – 81), however, have noted that activation of the sympathetic nervous system, induced via means such as 20 min of intense stationary cycling or running on a treadmill actually facilitates genital engorge- ment under conditions of erotic stimulation.

The  most  notable  anxiety  reduction  techniques  for  treating  female orgasmic disorder are systematic desensitization and sensate focus. Systematic desensitization for treating sexual anxiety was first described by Wolpe (82). The process involves training the woman to relax the muscles of her body through a sequence of exercises. Next, a hierarchy of anxiety-evoking stimuli or situations is composed and the woman is trained to imagine the situations while remaining relaxed. Once the woman is able to imagine all the items in the hierarchy without experiencing anxiety, she is instructed to engage in the activities in real life.

Sensate focus was originally conceived by Masters and Johnson (78). It involves a  step-by-step sequence of  body touching exercises, moving from nonsexual to increasingly sexual touching of one another’s body. Components specific for treating anorgasmic women often include nondemand genital touch- ing by the partner, female guidance of genital manual, and penile stimulation and coital positions designed to maximize pleasurable stimulation. Sensate focus is primarily a couple’s skills learning approach designed to increase communi- cation and awareness of sexually sensitive areas between partners. Conceptually, however, the removal of goal-focused orgasm, which can cause performance concerns, the hierarchical nature of the touching exercises, and the instruction not to advance to the next phase before feeling relaxed about the current one, suggest sensate focus is also largely an anxiety reduction technique and could be considered a modified form of in vivo desensitization.

The success of using anxiety reduction techniques for treating female orgasmic disorder is difficult to assess because most studies have used some combination of anxiety reduction, sexual techniques training, sex education, communication training, bibliotherapy, and Kegel exercises, and have not sys- tematically evaluated the independent contributions to treatment outcome. More- over, even within specific treatment modalities, considerable variation between studies  exists.  For  example,  systematic  desensitization  has  been  conducted both in vivo and imaginal, has used mainly progressive muscle relaxation but also drugs (83) and hypnotic techniques (84) to induce  relaxation, and has varied somewhat in the hierarchical construction of events. Furthermore, the rela- tive contribution of factors such as individual vs. group treatment, patient demo- graphics (age, marital status, education, religion), precise diagnosis and severity of presenting sexual concerns, therapist characteristics (sex, theoretical orien- tation and training), treatment settings (private,  hospital, university clinics), and length of treatment sessions and duration are often reported but systematic evaluation of many of these factors is missing from the literature. Finally, of the  controlled  studies that  have  included anxiety  reduction techniques, few have differentiated between treatment outcomes for primary and secondary anor- gasmic women. Across studies, women have reported decreases in sexual anxiety and, occasionally, increases in frequency of sexual intercourse and sexual satis- faction with systematic desensitization, but substantial improvements in orgas- mic ability have not been noted. Similarly, of the few controlled studies that have  included sensate focus as a treatment  component, none have  reported notable  increases  in  orgasmic  ability.  These  findings suggest  that,  in  most cases, anxiety does not appear to play a causal role in female orgasmic disorder and anxiety reduction techniques are best suited for anorgasmic women only when sexual anxiety is coexistant.

Other  Behavioral Techniques

As noted earlier, many treatment outcome studies for anorgasmia include a variety of treatment components, and the relevant individual contributions they make to treatment outcome success cannot be effectively evaluated. With this in mind, a number of additional treatment techniques warrant mention. Since Masters and Johnson’s pioneering work (78), sex education has been a com- ponent of many sex therapy programs. Ignorance about female anatomy and/ or techniques for maximizing pleasurable sensations can certainly contribute to orgasm  difficulties. Jankovich  and  Miller  (85)  noted  increases  in  orgasmic ability following an educational audiovisual presentation in seven of 17 women with primary anorgasmia. Kilmann et al. (86) compared the effectiveness of various sequences of sex education and communication skills vs. wait-list control on orgasmic ability in women with secondary anorgasmia. The authors found sex education to be beneficial for enhancing coital ability at posttest but not at 6 month follow-up. In a comparison study of the effectiveness of sex therapy vs. communication skills training for secondary anorgasmia, Everaerd and Dekker (87)  found  both  treatments  were  equally  effective  in  improving  orgasmic ability. Kegel (88) proposed that conducting exercises that strengthen the pubo- coccygeous muscle could increase vascularity to the genitals and, in turn, facili- tate orgasm. Treatment comparison studies have generally found no differences in orgasmic ability between women whose therapy included using Kegel exer- cises vs. those whose therapy did not. To the extent that Kegel exercise may enhance arousal and/or help the woman become more aware and comfortable with  her  genitals,  these  exercises  may  enhance  orgasm  ability  (69).  In summary, sex education, communication skills training, and Kegel exercises may serve as benefical adjuncts to therapy. Used alone, they do not appear highly effective for treating either primary or secondary anorgasmia.

Pharmacological Approaches

Of the few placebo-controlled studies examining the effectiveness of pharmaco- logical agents for treating female orgasmic disorder, most examine the efficacy of agents for treating antidepressant-induced anorgasmia. Whether pharmacological agents would have the same treatment outcome effect on non-drug- vs. drug- induced anorgasmia is not known.

Modell et al. (89) reported no significant effect beyond placebo of either 150 or 300 mg/day bupropion-SR on orgasm in 20 women with delayed or inhib- ited orgasm. Ito et al. (90) conducted a double-blind, placebo-controlled study of ArginMax, a nutritional supplement comprising ginseng, Ginkgo biloba, Damiana leaf, and various vitamins, on sexual function in 77 women with unspe- cified sexual function. Approximately 47% of women treated with ArginMax reported  an  increase  in  the  frequency of  orgasm compared  with    30%  of women  treated  with  placebo—a  marginally  significant group  difference.  It cannot be determined from the report how many women would meet a clinical diagnosis for  anorgasmia.  To  date,  there  have  been  no  published placebo- controlled studies on sildenafil for female anorgasmia and findings from uncon- trolled studies are equivocal. In an open-label trial, Kaplan et al. (44) reported a very modest 7.4% improvement in orgasm at 12 weeks with 50 mg sildenafil. Participants were 30 post-menopausal women with self-reported mixed sexual dysfunction.

As noted earlier, there is a high incidence of adverse sexual side effects noted with antidepressant treatment. A number of pharmacological agents have been prescribed along with the antidepressant medication in an effort to help counter these effects. Some such drugs include antiserotonergic agents such as cyproheptadine, buspirone, mirtazapine, and granisetron; dopaminergic agents such as amantadine, dextroamphetamine, bupropion, methylphenidate, and pemoline;  adrenergic  agents  such  as  yohimbine  and  ephedrine;  cholinergic agents such as bethanechol; and the selective cyclic-GMP catabolism inhibitor sildenafil. A number of case reports and open-label studies report success in alle- viating SSRI-induced anorgasmia with some of these agents. Findings from the few placebo-controlled studies published are less optimistic. Michelson et al. (91) examined the comparative effects of 8 weeks of treatment with buspirone (n ¼ 19),  amantadine  (n ¼ 18),  or  placebo  (n ¼ 20)  on  fluoxetine-induced sexual dysfunction in premenopausal women reporting either impaired orgasm or sexual arousal. The authors reported all groups experienced an improvement in orgasm during treatment, but neither buspirone nor amantadine was more effec- tive than placebo in restoring orgasmic function. It should be noted, however, that the doses of buspirone (20 mg/day) and amantadine (50 mg/day) administered were very low. At a higher dose level (mean daily dose ¼ 47 mg), buspirone showed a marginally significant alleviation of sexual side effects in women taking either citalopram or paroxetine compared with placebo (92). The authors did not distinguish between orgasm and desire disorders in either the classification of patients or treatment outcome. In a randomized, double-blind, parallel, placebo- controlled   study   of   mirtazapine   (15 mg/day),    yohimbine   (5.4 mg/day), olanzapine (0.25 mg/day), or placebo for fluoxetine-induced sexual dysfunction, Michelson et  al.  (93) found no significant improvement in  orgasmic  ability beyond placebo in 107 women with either impaired orgasm or vaginal lubrication. Kang et al. (94) reported no significant effect of Gingko biloba beyond placebo in a small  group of  women  with  SSRI-induced sexual dysfunction. Meston (95) reported no significant effect  of  ephedrine (50 mg, 1 h  prior to  intercourse) beyond placebo on orgasmic function in 19 women with sexual side effects second- ary to fluoxetine, sertraline, or paroxetine treatment. The study was conducted using a randomized, double-blind, placebo-controlled, cross-over design. In summary, to date there are no pharmacological agents proven to be beneficial beyond placebo in enhancing orgasmic function in women.

CONCLUSIONS

We conclude that DM is an empirically valid and efficacious treatment for lifelong female orgasmic disorder. To date, there are no empirically validated treatments for acquired female orgasmic disorder. Anxiety reduction techniques such as sensate focus and systematic desensitization have not been shown to be efficacious for treating either lifelong or acquired female orgasmic disorder. Anxiety reduction techniques may serve as beneficial adjuncts to therapy if the woman is experiencing a high level of anxiety. There is no direct empirical evidence to suggest that sex education, communication skills training, or Kegel exercises alone  are  effective  for treating  either  lifelong  or  acquired female orgasmic disorder. Of the few studies examining the effects of pharmacological agents for female orgasmic disorder, none have been shown to be more effective than placebo. Placebo-controlled research is essential to examine the effective- ness of agents with demonstrated success in case series or open-label trials (i.e., sildenafil, testosterone) on orgasmic function in women.

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